内容摘要：冷冻技术发展小史大脑的“暂停”挑战低温技术的现实意义参考文献[1] German A, Akdaş EY, Flügel-Koch C, et al. Functional recovery of t

冷冻技术发展小史

大脑的三体“暂停”挑战

低温技术的现实意义

参考文献

[1] German A, Akdaş EY, Flügel-Koch C, et al. Functional recovery of the adult murine hippocampus after cryopreservation by vitrification. Proc Natl Acad Sci U S A. 2026 Mar 10;123(10):e2516848123.

[2] Luyet, B.J. and Hodapp, E.L.Revival of Frog’s Spermatozoa Vitrified in Liquid Air. Proceedings of the Society for Experimental Biology and Medicine, 1938;39:433-434.

[3] Luyet, B.J. Life and Death at Low Temperatures. Normandy, Missouri: Biodynamica; 1940.

[4] PolgeC, Smith AU, Parkes AS. Revival of spermatozoa after vitrification and dehydration at low temperatures. Nature. 1949 Oct 15;164(4172):666.

[5] Fahy GM, MacFarlane DR, Angell CA, Meryman HT. Vitrification as an approach to cryopreservation. Cryobiology. 1984;21(4):407-426.

[6] Kheirabadi BS, Fahy GM. Permanent life support by kidneys perfused with a vitrifiable (7.5 molar) cryoprotectant solution. Transplantation. 2000 Jul 15;70(1):51-7.

[7] Fahy GM, Wowk B, Pagotan R, Chang A, Phan J, Thomson B, Phan L. Physical and biological aspects of renal vitrification. Organogenesis. 2009 Jul;5(3):167-75.

[8] McIntyre RL, Fahy GM. Aldehyde-stabilized cryopreservation. Cryobiology. 2015 Dec;71(3):448-58.

[9] Manuchehrabadi N, Gao Z, Zhang J, et al. Improved tissue cryopreservation using inductive heating of magnetic nanoparticles. Sci Transl Med. 2017 Mar 1;9(379):eaah4586.

[10] Han Z, Rao JS, Gangwar L, et al.Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model. Nat Commun. 2023 Jun 9;14(1):3407.

[11] Ramesh S, Rao JS, Namsrai BE, et al. Vitrification and rapid rewarming of precision-cut liver slices for pharmacological and biomedical research. Bioeng Transl Med. 2025 Jul 17;11(1):e70045.

策划制作

来源丨返朴（id:fanpu2019）

作者丨顾舒晨

责编丨钟艳平

审校丨徐来、张林林

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